Our pharmacist answers the latest question regarding whether or not your deserve to take Benadryl (diphenhydramine) v Nyquil.

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At a glance

NyQuil includes doxylamine, a sedating first-generation antihistamine. Benadryl contains diphenhydramine, additionally a sedating first-generation antihistamine. Usage of both together boosts the danger of side effects such together oversedation, dry mouth, dry eyes and constipation.



In many cases, it is not encourage to take Benadryl (diphenhydramine) and Nyquil together since they both save sedating antihistamines.<1>

The sedating antihistamine in NyQuil is doxylamine, i m sorry is really closely pertained to diphenhydramine (the energetic ingredient in Benadryl). In fact, they are in the same class of medication, sedating first-generation antihistamines.

Taking two first-generation antihistamines together is considered "duplicate therapy" and increases the danger of side effects occurring.

What Is Benadryl?

Benadryl is classified together a very first generation antihistamine. The expression of activity of the drug is commonly 4-6 hours per sheep (25 mg come 50 mg).<2>

First generation antihistamines are known for your sedative effects and CNS (central concerned system) depressant effects. Plenty of individuals can not tolerate the sedative results of Benadryl (diphenhydramine) throughout the job and, therefore, only take it at bedtime come combat insomnia.

What Is NyQuil?

Nyquil is a combination cold/cough product that contains the medicine doxylamine, along with a pain/fever reducer (acetaminophen) and a sneeze suppressant (dextromethorphan).

Doxylamine is a sedating first-generation antihistamine and is in the same course of medication as Benadryl (diphenhydramine).<3>

Interaction Explained

As proclaimed above, both doxylamine and also Benadryl (diphenhydramine) work-related the same way and are actually in the same class of medication.

They job-related by blocking the histamine-1 receptor in the body, which avoids histamine from binding to it and also producing the symptom we room all very familiar through (e.g. Runny nose, watery eyes, etc...).

Since both drugs job-related the exact same way, utilizing both in ~ the very same time is no recommended.

Combined use typically won"t provide any much more benefit than taking one of two people alone. Additionally, taking them together not only increases the risk of too much sedation, it greatly increases the danger of extr adverse results such as:<4>

Dry mouthDry eyesConstipationConstricted airways

Very high sheep of sedating antihistamines have also been associated with excitation, agitation, and restlessness.<5>

When Is Use together Okay?

Having said that, there might be a case to take it the mix together.

Benadryl (diphenhydramine) has reasonably strong proof for usage in stemming allergic reactions.

Studies present that Benadryl (diphenhydramine) can successfully reduce itching and also swelling from reactions to things like bee stings and poison ivy.

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If you have currently taken a dose of Nyquil and are having actually an allergic reaction come something, taking a dose of Benadryl (diphenhydramine) may aid without a huge increased danger in intolerable side effects.