Main difference – primary vs second Active Transport

Active transport is the movement of molecules across the cabinet membrane against the concentration gradient v the assistance of enzymes and also usage of moving energy. Energetic transport is divided into two varieties known as primary and an additional active transport depending on the source of power used in the transport of molecules. The main difference in between primary and an additional active carry is the molecules space transported by the failure of ATP in primary active transport, whereas in secondary active transport, the concentration gradient of one molecule offers the energy for the deliver of an additional molecule versus the latter’s concentration gradient.

Key areas Covered

1. What is Primary active Transport – Definition, Types, Characteristics 2. What is an additional Active carry – Definition, Types, Characteristics 3. What are the similarities in between Primary and secondary Active Transport – summary of typical Features 4. What is the difference between Primary and an additional Active move – comparison of an essential Differences

Key Terms: Antiport, ATP, Concentration Gradient, Electrochemical Gradient, Ion-coupled Transport, Primary active Transport, secondary Active Transport, Symport, Transmembrane Proteins


What is Primary energetic Transport

Primary energetic transport is the transfer of molecules against a concentration gradient by the usage of energy from ATP. Transmembrane proteins are involved in administrate the i of molecules throughout the cell membrane. They contain one or more ATP binding sites on your cytosolic face. Throughout primary energetic transport, the power is transferred to the transmembrane protein and also then come the concentration gradient. The primary energetic transport is most evident in sodium/potassium pump (Na+/K+ ATPase), which maintains the relaxing potential the cells. Hydrolysis of an ATP pumps 3 sodium ion out that the cell and also two potassium ions right into the cell. Here, sodium ions are transported from a reduced concentration of 10 mM to a greater concentration of 145 mM. Potassium ions room transported native a 140 mM concentration inside the cell to a 5 mM concentration of the extracellular fluid. The proton/potassium pump (H+/K+ ATPase) is found in the lining that the stomach, maintaining an acidic environment in the stomach.

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Figure 1: Sodium-Potassium Pump

What is an additional Active Transport

Secondary energetic transport is the another form of active transport that provides the electrochemical gradient in the deliver of molecules versus the concentration gradient. Transmembrane proteins affiliated in the an additional active carry are determined as cotransporters because they deliver two varieties of molecules at the same time. On that account, secondary active move is referred to the ion-coupled transport. Typically, an ion (driving ion) is transported with its electrochemical gradient while another ion or solute (driven ion/molecule) is transported versus the electrochemical gradient. The concentration gradient of the control ion provides the power for the carry of driven ion/molecule against latter’s concentration gradient. The maintain of the concentration gradient the the steering ion is achieved by primary active transport.

Symport and antiport space the two varieties of an additional active transport. In symport, both driving and driven molecules room transported in the same direction. The Na+/glucose cotransporter (SGLT1) is an instance for symports in i m sorry both sodium and glucose room transported into the cell. That is discovered in kidney proximal tubules and the tiny intestine. In antiport, driving and driven ions room transported in opposing directions. The Na+/Ca2+ exchanger (NCX) in muscle cell transports sodium ions into the cabinet while calcium ions room transported out of the cell. The sodium/glucose pump is shown in figure 2.


Figure 2: Sodium/Glucose Pump

Similarities between Primary and second Active Transport

Both primary energetic transport and an additional active transport are two energetic transport methods.Both techniques are connected in the pumping of molecules against the concentration gradient, native a short concentration to a high concentration.Transmembrane protein are affiliated in facilitating both primary and an additional active transport.Transmembrane proteins are specific to the molecule transported across the membrane.The main purpose that both transportation approaches is to speed up the movement of molecules throughout the cabinet membrane.

Difference in between Primary and secondary Active Transport


Primary energetic Transport: Primary energetic transport is the deliver of molecules versus a concentration gradient through the use of energy from ATP.

Secondary active Transport: Secondary active transport is the move of two different molecules across a move membrane using power in other creates than ATP.

Coupled Transport

Primary active Transport: A solitary molecule is transported in primary energetic transport.

Secondary active Transport: Two types of molecules room transported at when in secondary active transport.

Source the Energy

Primary energetic Transport: Primary energetic transport uses energy from ATP.

Secondary energetic Transport: The concentration gradient that the steering ion gives the power for the carry of thrust ion/molecule against its concentration gradient in an additional active transport. 

Types the Molecules

Primary energetic Transport: Ions prefer sodium, potassium, and calcium are transported across the cabinet membrane in primary active transport.

Secondary energetic Transport: Ions offer as control molecules, while ion or various other molecules serve as moved molecules.


Primary energetic Transport: Transmembrane proteins are distinct to the ion transported with them.

Secondary active Transport: Symports and also antiports are the two species of transmembrane protein in an additional active transport.

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Primary energetic Transport: Sodium-potassium pump, calcium pump in the muscles, and also proton pump in the stomach space the instances of the primary energetic transport.

Secondary active Transport: Glucose-sodium pump, Na+/Ca2+ exchanger, and sodium/phosphate cotransporter are the examples of secondary active transport. 


Primary and second active transport room the 2 variations of active transport the molecules across biological membranes. The key difference between primary and second active transport is the source of power used by each transport method in bespeak to carry molecules across the cell membrane. Primary active transport uses the energy of ATP to move a single molecule in ~ a time across the cabinet membrane. Secondary active transport transports two molecules across the membrane in ~ a time; the concentration gradient of the control ion provides power for the deliver of thrust molecule in an additional active transport. 


1. “Active transport.” cannes Academy. N.p., n.d. Web. Available here. 15 June 2017. 2. “Primary energetic Transport.” Boundless. N.p., 26 may 2016. Web. Obtainable here. 15 June 2017.3. “Secondary energetic Transport.” PhysiologyWeb. N.p., n.d. Web. Available here. 15 June 2017. 

Image Courtesy:

1. “Blausen 0818 Sodium-PotassiumPump” employee (2014). “Medical gallery of Blausen medical 2014”. WikiJournal of medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436. – Own work (CC by 3.0) via Commons Wikimedia2. “Figure 05 03 04” by CNX OpenStax –(CC by 4.0) via Commons Wikimedia