What Is Duragesic and also how is the used?

Duragesic is a prescription medication used as a transdermal patch come treat the symptom of chronic, serious pain in opioid-tolerant patients. Duragesic might be used alone or with various other medications.

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Duragesic is an opioid analgesics.

It is not known if Duragesic is safe and also effective in kids younger 보다 2 year of age.

What space Side impacts of Duragesic?

Common side impacts of Duragesic include:

slow heart rate,weak or shallow breathing,confusion,severe drowsiness feeling like you might pass out,chest pain, quick or pounding heartbeats,

Get medical aid right away, if you have any kind of of the symptoms noted above.

The most common side effects of Duragesic include:

headache,dizziness,drowsiness,tiredness,nausea,vomiting,stomach pain,diarrhea,constipation,itching, redness, or a rash where a patch to be worn,difficulty falling sleep (insomnia),increased sweating or cold feeling,

Tell the doctor if girlfriend have any side impact that bothers girlfriend or that does not go away.

These are not all the feasible side results of Duragesic. For an ext information, ask your medical professional or pharmacist.

Call your medical professional for medical advice about side effects. You may report side effects to FDA in ~ 1-800-FDA-1088.


WARNING

ADDICTION, ABUSE, and also MISUSE; LIFE-THREATENING respiratory tract DEPRESSION; inadvertently EXPOSURE; NEONATAL OPIOID tap the money SYNDROME; CYTOCHROME P450 3A4 INTERACTION; and also EXPOSURE to HEAT

Addiction, Abuse, and Misuse

DURAGESIC exposes patients and also other users to the dangers of opioid addiction, abuse, and misuse, which can lead to overdose and death. Assess each patient's risk prior to prescribing DURAGESIC, and monitor every patients on regular basis for the development of these actions or problems .

Life-threatening respiratory Depression

Serious, life-threatening, or fatal respiratory depression may take place with use of DURAGESIC, also when supplied as recommended. Screen for respiratory depression, especially during initiation the DURAGESIC or adhering to a sheep increase. Due to the fact that of the threat of respiratory tract depression, DURAGESIC is contraindicated for use as one as-needed analgesic, in non-opioid tolerant patients, in acute pain, and in postoperative pain .

Accidental Exposure

Deaths as result of a deadly overdose of fentanyl have arisen when children and also adults to be accidentally exposed come DURAGESIC. Strictly adherence to the recommended handling and disposal instructions is of the utmost prominence to avoid accidental exposure .

Neonatal Opioid tap the money Syndrome

Prolonged usage of DURAGESIC throughout pregnancy can result in neonatal opioid withdrawal syndrome, which might be life-threatening if no recognized and treated, and also requires administration according to protocols emerged by neonatology experts. If opioid use is forced for a lengthy period in a pregnant woman, advise the patience of the hazard of neonatal opioid withdrawal syndrome and also ensure that ideal treatment will certainly be available .

Cytochrome P450 3A4 Interaction

The concomitant use of DURAGESIC with all cytochrome P450 3A4 inhibitors may result in an increase in fentanyl plasma concentrations, which could increase or prolong adverse drug effects and may cause potentially fatal respiratory tract depression. In addition, discontinuation that a concomitantly used cytochrome P450 3A4 inducer may an outcome in rise in fentanyl plasma concentration. Monitor patients receiving DURAGESIC and any CYP3A4 inhibitor or inducer .

Exposure to Heat

Exposure of the DURAGESIC applications site and also surrounding area to straight external warm credits, such together heating pads or electrical blankets, warmth or tan lamps, sunbathing, warm baths, saunas, warm tubs, and also heated water beds may rise fentanyl absorption and has brought about fatal overdose that fentanyl and also death . Patient wearing DURAGESIC systems who construct fever or increased core human body temperature because of strenuous exertion are likewise at danger for increased fentanyl exposure and also may need an convey in the sheep of DURAGESIC to protect against overdose and also death .


DESCRIPTION

DURAGESIC (fentanyl transdermal system) is a transdermal mechanism containing fentanyl. The chemical surname is N-Phenyl-N-(1-(2-phenylethyl)-4-piperidinyl) propanamide. The structure formula is:

*

The molecular load of fentanyl basic is 336.5, and also the empirical formula is C22H28N2O. The n-octanol: water partition coefficient is 860:1. The pKa is 8.4.

System Components and Structure

The lot of fentanyl released from each device per hour is proportional to the surface ar area (25 mcg/h every 10.5 cm²). The composition per unit area that all mechanism sizes is identical.

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Dose* (mcg/h)Size (cm²)Fentanyl contents (mg)
12**5.252.1
2510.54.2
50218.4
7531.512.6
1004216.8
**Nominal shipment rate every hour***Nominal distribution rate is 12.5 mcg/hr

DURAGESIC is a rectangular transparent unit consisting of a security liner and two useful layers. Proceeding native the external surface toward the surface adhering to skin, these layers are:

1) a backing great of polyester/ethyl vinyl acetate film; 2) a drug-in-adhesive layer. Prior to use, a protective liner extending the adhesive layer is removed and also discarded.