Calcitonin is a hormone that is produced and also released through the C-cells that the thyroid gland. The biological role in people is to have a relatively minor function in calcium balance.

Alternative names for calcitonin

CT; thyrocalcitonin

What is calcitonin?

Calcitonin is a hormone the is developed in humans by the parafollicular cells (commonly known as C-cells) that the thyroid gland\" data-content=\"1456\" >thyroid gland. Calcitonin is affiliated in help to regulate levels that calcium and also phosphate in the blood, the contrary the activity of parathyroid hormone. This method that the acts to minimize calcium levels in the blood. However, the prestige of this role in humans is unclear, together patients who have very low or really high level of calcitonin show no disadvantage effects. 

Calcitonin reduce calcium level in the blood through two key mechanisms:

It inhibits the task of osteoclasts, which are the cell responsible for breaking under bone. As soon as bone is broken down, the calcium consisted of in the bone is released right into the bloodstream. Therefore, the inhibition the the osteoclasts by calcitonin straight reduces the lot of calcium released right into the blood. However, this inhibition has been presented to be short-lived.

Manufactured forms of calcitonin have, in the past, been provided to act Paget’s an illness of bone and sometimes hypercalcaemia and also bone pain. However, through the development of newer drugs, such together bisphosphonates, their usage is now very limited.

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How is calcitonin controlled?

The secretion of both calcitonin and parathyroid hormone is determined by the level the calcium in the blood. When levels of calcium in the blood increase, calcitonin is secreted in higher quantities. As soon as levels of calcium in the blood decrease, this causes the amount of calcitonin secreted come decrease too.

The cheap of calcitonin is also inhibited through the hormone somatostatin, i m sorry can likewise be released by the C-cells in the thyroid gland.

What wake up if I have actually too much calcitonin?

There does no seem to be any direct deleterious effect on the body together a result of having too lot calcitonin.

Medullary thyroid cancer is a rare kind of cancer the arises native the C-cells in the thyroid gland that secrete calcitonin. It is sometimes associated with multiple endocrine neoplasia form 2a and also multiple endocrine neoplasia form 2b. Patients through medullary thyroid cancer have high calcitonin level in their bloodstream. However, that is vital to note that these high calcitonin levels space a consequence of this condition, no a straight causal factor.

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What wake up if I have actually too little calcitonin?

There does not seem to be any type of clinical result on the body as a an outcome of having actually too little calcitonin. Patients that have had their thyroid gland removed, and also have undetectable level of calcitonin in their blood, show no disadvantage symptoms or indications as a result of this.